Category: Publications
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Chambers SEJ, O'Neill CL, Guduric-Fuchs J, McLoughlin KJ, Liew A, Egan AM, O'Brien T, Stitt AW, Medina RJ. The Vasoreparative Function of Myeloid Angiogenic Cells Is Impaired in Diabetes Through the Induction of IL1β.  Stem Cells. 2018 Feb 27. doi: 10.1002/stem.2810. [Epub ahead of print] PMID:29484768

Reid E, Guduric-Fuchs J, O'Neill CL, Allen LD, Chambers SEJ, Stitt AW, Medina RJ. Preclinical Evaluation and Optimization of a Cell Therapy Using Human Cord Blood-Derived Endothelial Colony-Forming Cells for Ischemic Retinopathies. Stem Cells Transl Med. 2018 Jan;7(1):59-67. doi: 10.1002/sctm.17-0187. Epub 2017 Nov 22. PMID:29164803 Free PMC Article

Dellett M, Brown ED, Guduric-Fuchs J, O'Connor A, Stitt AW, Medina RJ, Simpson DA. MicroRNA-containing extracellular vesicles released from endothelial colony-forming cells modulate angiogenesis during ischaemic retinopathy. J Cell Mol Med. 2017 Dec;21(12):3405-3419. doi: 10.1111/jcmm.13251. Epub 2017 Jun 20. PMID:28631889 Free PMC Article

Medina RJ, Barber CL, Sabatier F, Dignat-George F, Melero-Martin JM, Khosrotehrani K, Ohneda O, Randi AM, Chan JKY, Yamaguchi T, Van Hinsbergh VWM, Yoder MC, Stitt AW. Endothelial Progenitors: A Consensus Statement on Nomenclature. Stem Cells Transl Med. 2017 May;6(5):1316-1320. doi: 10.1002/sctm.16-0360. PMID:28296182  Free PMC Article

Hookham MB, Ali IH, O'Neill CL, Hackett E, Lambe MH, Schmidt T, Medina RJ, Chamney S, Rao B, McLoone E, Sweet D, Stitt AW, Brazil DP. Hypoxia-induced responses by endothelial colony-forming cells are modulated by placental growth factor. Stem Cell Res Ther. 2016 Nov 29;7(1):173. PMID:27899144  Free PMC Article


O'Neill CL, Guduric-Fuchs J, Chambers SE, O'Doherty M, Bottazzi B, Stitt AW, Medina RJ. Endothelial cell-derived Pentraxin 3 limits the vasoreparative therapeutic potential of Circulating Angiogenic Cells. Cardiovasc Res. 2016 Sep 22. PubMed PMID:27659714

Cahoon JM, Rai RR, Carroll LS, Uehara H, Zhang X, O'Neil CL, Medina RJ, Das SK, Muddana SK, Olson PR, Nielson S, Walker K, Flood MM, Messenger WB, Archer BJ, Barabas P, Krizaj D, Gibson CC, Li DY, Koh GY, Gao G, Stitt AW, Ambati BK.

Intravitreal AAV2.COMP-Ang1 Prevents Neurovascular Degeneration in a Murine Model of Diabetic Retinopathy.

Diabetes. 2015; 64(12):4247-59. PubMed PMID:26340930, PMCID: PMC4657578

Stitt AW, Curtis TM, Chen M, Medina RJ, McKay GJ, Jenkins A, Gardiner TA, Lyons TJ, Hammes HP, Simó R, Lois N.

The progress in understanding and treatment of diabetic retinopathy.

Progress in retinal and eye research. 2016; 51:156-86. PubMed PMID: 26297071

Rajasekar P, O'Neill CL, Eeles L, Stitt AW, Medina RJ.

Epigenetic Changes in Endothelial Progenitors as a Possible Cellular Basis for Glycemic Memory in

Diabetic Vascular Complications.

Journal of diabetes research. 2015; 2015:436879. PubMed PMID: 26106624, PMCID: PMC4464584

Prasain N, Lee MR, Vemula S, Meador JL, Yoshimoto M, Ferkowicz MJ, Fett A, Gupta M, Rapp BM, Saadatzadeh MR, Ginsberg M, Elemento O, Lee Y, Voytik-Harbin SL, Chung HM, Hong KS, Reid E, O'Neill CL, Medina RJ, Stitt AW, Murphy MP, Rafii S,

Broxmeyer HE, Yoder MC.

Differentiation of human pluripotent stem cells to cells similar to cord-blood endothelial colony-forming cells.

Nature biotechnology. 2014; 32(11):1151-7. PubMed PMID: 25306246, PMCID: PMC4318247

Lois N, McCarter RV, O'Neill C, Medina RJ, Stitt AW.

Endothelial progenitor cells in diabetic retinopathy.

Frontiers in endocrinology. 2014; 5:44. PubMed PMID: 24782825, PMCID: PMC3988370

Chambers SE, O'Neill CL, O'Doherty TM, Medina RJ, Stitt AW.

The role of immune-related myeloid cells in angiogenesis.

Immunobiology. 2013; 218(11):1370-5. PubMed PMID: 23932437

Medina RJ, O'Neill CL, O'Doherty TM, Chambers SE, Guduric-Fuchs J, Neisen J, Waugh DJ, Simpson DA, Stitt AW.

Ex vivo expansion of human outgrowth endothelialcells leads to IL-8-mediated replicative senescence and impaired vasoreparative function.

Stem cells (Dayton, Ohio). 2013; 31(8):1657-68. PubMed PMID: 23629812

Stitt AW, Lois N, Medina RJ, Adamson P, Curtis TM.

Advances in our understanding of diabetic retinopathy.

Clinical science. 2013; 125(1):1-17. PubMed PMID: 23485060

Jarajapu YP, Bhatwadekar AD, Caballero S, Hazra S, Shenoy V, Medina R, Kent D, Stitt AW, Thut C, Finney EM, Raizada MK, Grant MB.

Activation of the ACE2/angiotensin-(1-7)/Mas receptor axis enhances the reparative function of dysfunctional diabetic endothelial progenitors.

Diabetes. 2013; 62(4):1258-69. PubMed PMID: 23230080, PMCID: PMC3609564

O'Neill CL, O'Doherty MT, Wilson SE, Rana AA, Hirst CE, Stitt AW, Medina RJ.

Therapeutic revascularisation of ischaemic tissue: the opportunities and challenges for therapy using vascular stem/progenitor cells.

Stem cell research & therapy. 2012; 3(4):31. PubMed PMID: 22897941, PMCID: PMC3580469

Guduric-Fuchs J, O'Connor A, Camp B, O'Neill CL, Medina RJ, Simpson DA.

Selective extracellular vesicle-mediated export of an overlapping set of microRNAs from multiple cell types.

BMC genomics. 2012; 13:357. PubMed PMID: 22849433, PMCID: PMC3532190

Liu Y, Teoh SH, Chong MS, Lee ES, Mattar CN, Randhawa NK, Zhang ZY, Medina RJ, Kamm RD, Fisk NM, Choolani M, Chan JK.

Vasculogenic and osteogenesis-enhancing potential of human umbilical cord blood endothelial colony-forming cells.

Stem cells (Dayton, Ohio). 2012; 30(9):1911-24. PubMed PMID: 22761003

Medina RJ, O'Neill CL, O'Doherty TM, Wilson SE, Stitt AW.

Endothelial progenitors as tools to study vascular disease.

Stem cells international. 2012; 2012:346735. PubMed PMID: 22550504, PMCID: PMC3329655

Guduric-Fuchs J, O'Connor A, Cullen A, Harwood L, Medina RJ, O'Neill CL, Stitt AW, Curtis TM, Simpson DA.

Deep sequencing reveals predominant expression of miR-21 amongst the small non-coding RNAs in retinal microvascular endothelial cells.

Journal of cellular biochemistry. 2012; 113(6):2098-111. PubMed PMID: 22298343, PMCID: PMC3708110

Medina RJ, Archer DB, Stitt AW.

Eyes open to stem cells: safety trial may pave the way for cell therapy to treat retinal disease in patients.

Stem cell research & therapy. 2011; 2(6):47. PubMed PMID: 22152341, PMCID: PMC3340556

Medina RJ, O'Neill CL, O'Doherty TM, Knott H, Guduric-Fuchs J, Gardiner TA, Stitt AW.

Myeloid angiogenic cells act as alternative M2 macrophages and modulate angiogenesis through interleukin-8.

Molecular medicine (Cambridge, Mass.). 2011; 17(9-10):1045-55. PubMed PMID: 21670847, PMCID: PMC3188859

Stitt AW, O'Neill CL, O'Doherty MT, Archer DB, Gardiner TA, Medina RJ.

Vascular stem cells and ischaemic retinopathies.

Progress in retinal and eye research. 2011; 30(3):149-66. PubMed PMID: 21352947

Yong PH, Zong H, Medina RJ, Limb GA, Uchida K, Stitt AW, Curtis TM.

Evidence supporting a role for N-(3-formyl-3,4-dehydropiperidino)lysine accumulation in Müller glia dysfunction and death in diabetic retinopathy.

Molecular vision. 2010; 16:2524-38. PubMed PMID: 21151599, PMCID: PMC3000235

Yamamoto K, Sakaguchi M, Medina RJ, Niida A, Sakaguchi Y, Miyazaki M, Kataoka K, Huh NH.

Transcriptional regulation of a brown adipocyte-specific gene, UCP1, by KLF11 and KLF15.

Biochemical and biophysical research communications. 2010; 400(1):175-80. PubMed PMID: 20709022

McVicar CM, Colhoun LM, Abrahams JL, Kitson CL, Hamilton R, Medina RJ, Durga D, Gardiner TA, Rudd PM, Stitt AW. Differential modulation of angiogenesis by erythropoiesis-stimulating agents in a mouse model of ischaemic retinopathy.

PloS one. 2010; 5(7):e11870. PubMed PMID: 20686695, PMCID: PMC2912370

Medina RJ, O'Neill CL, Humphreys MW, Gardiner TA, Stitt AW.

Outgrowth endothelial cells: characterization and their potential for reversing ischemic retinopathy.

Investigative ophthalmology & visual science. 2010; 51(11):5906-13. PubMed PMID: 20554606

Medina RJ, O'Neill CL, Sweeney M, Guduric-Fuchs J, Gardiner TA, Simpson DA, Stitt AW.

Molecular analysis of endothelial progenitor cell (EPC) subtypes reveals two distinct cell populations with different identities.

BMC medical genomics. 2010; 3:18. PubMed PMID: 20465783, PMCID: PMC2881111

Yang XZ, Kataoka K, Medina R, Yamamoto K, Than SS, Miyazaki M, Huh NH.

A novel three-dimensional culture system for isolation and clonal propagation of neural stem cells using a thermo-reversible gelation polymer.

Tissue engineering. Part C, Methods. 2009; 15(4):615-23. PubMed PMID: 19231918

Medina RJ, O'Neill CL, Devine AB, Gardiner TA, Stitt AW.

The pleiotropic effects of simvastatin on retinal microvascular endothelium has important implications for ischaemic retinopathies.

PloS one. 2008; 3(7):e2584. PubMed PMID: 18612412, PMCID: PMC2440506

Miyazaki M, Hardjo M, Masaka T, Tomiyama K, Mahmut N, Medina RJ, Niida A, Sonegawa H, Du G, Yong R, Takaishi M, Sakaguchi M, Huh NH.

Isolation of a bone marrow-derived stem cell line with high proliferation potential and its application for preventing acute fatal liver failure.

Stem cells (Dayton, Ohio). 2007; 25(11):2855-63. PubMed PMID: 17702985

Medina RJ, Kataoka K, Miyazaki M, Huh NH.

Efficient differentiation into skin cells of bone marrow cells recovered in a pellet after density gradient fractionation.

International journal of molecular medicine. 2006; 17(5):721-7. PubMed PMID: 16596253

Medina RJ, Kataoka K, Takaishi M, Miyazaki M, Huh NH.

Isolation of epithelial stem cells from dermis by a three-dimensional culture system.

Journal of cellular biochemistry. 2006; 98(1):174-84. PubMed PMID: 16408300

Kataoka K, Medina RJ, Kageyama T, Miyazaki M, Yoshino T, Makino T, Huh NH.

Participation of adult mouse bone marrow cells in reconstitution of skin.

The American journal of pathology. 2003; 163(4):1227-31. PubMed PMID: 14507632, PMCID: PMC1868321